In vitro interaction between normal cynolmolgus monkey alveolar macrophages and Legionnaires disease bacteria.

Formation of a Novel Phagosome by the Legionnaires' Disease Bacterium

Legionella pneumophila, the agent of Legionnaires' disease, is a facultative intracellular gram-negative bacterial pathogen (1) . The bacterium multiplies intracellularly in human blood monocytes (1) and human alveolar macrophages (2), and under tissue culture conditions, multiplication is exclusively intracellular . L. pneumophla enters monocytes by an unusual process-a monocyte pseudopod coil...

Mechanistic modelling of the communication between alveolar macrophages and epithelial cells during Legionella pneumophila infection

Metabolism of the vacuolar pathogen Legionella and implications for virulence

Legionella pneumophila is a ubiquitous environmental bacterium that thrives in fresh water habitats, either as planktonic form or as part of biofilms. The bacteria also grow intracellularly in free-living protozoa as well as in mammalian alveolar macrophages, thus triggering a potentially fatal pneumonia called "Legionnaires' disease." To establish its intracellular niche termed the "Legionella...

Cooperation between Monocyte-Derived Cells and Lymphoid Cells in the Acute Response to a Bacterial Lung Pathogen

Legionella pneumophila is the causative agent of Legionnaires' disease, a potentially fatal lung infection. Alveolar macrophages support intracellular replication of L. pneumophila, however the contributions of other immune cell types to bacterial killing during infection are unclear. Here, we used recently described methods to characterise the major inflammatory cells in lung after acute respi...

Legionnaires' disease pneumonia: histopathologic features and comparison with microbial and chemical pneumonias.

The histopathologic findings in lung tissue are reported from five cases of Philadelphia Legionnaire's Disease and the results are compared to pneumonias caused by other microbial and chemical agents. Histopathology of lung tissue was similar in all cases, despite the fact that death occurred between the fourth and 14th day of clinical illness. The inflammatory response was almost totally limit...